Showing posts with label contaminants. Show all posts
Showing posts with label contaminants. Show all posts

Monday, April 20, 2020

CDC’s Misuse of EVALI Misleads Americans That Smoking Safer Than Vaping

In a campaign of disinformation, culminating in the prolonged mischaracterization of the EVALI (e-cigarette, or vaping, associated lung injuries) crisis, the Centers for Disease Control and Prevention has caused more Americans to believe the untruth that vaping is more dangerous than cigarette smoking.

Bentley University economist Dhaval Dave and colleagues at the City University of New York and Cornell have authored an article titled “News That Takes Your Breath Away: Risk Perceptions During an Outbreak of Vaping-Related Lung Injuries,” published by the National Bureau of Economic Research.  It analyzes the effect of actions taken by the CDC.

Dave et al. describe the federal response to EVALI: “Statements issued by the CDC during the early ‘crisis’ period were direct and clear suggesting that individuals should stop using all vaping products in the late summer of 2019.” (emphasis added). 

The CDC was silent on marijuana until December 10, 2019, when it acknowledged in a tweet that “products that contain THC, particularly from informal sources…play a major role in the current lung injury outbreak.”  The agency had delayed focusing public attention on cannabis products for over three months, as it was clear by early September to many observers, including me (here) and Boston University’s Dr. Michael Siegel (here), that the lung injuries were unrelated to nicotine-based e-cigarettes and vaping products which had been used by tens of millions of consumers for some 10 years with no serious lung problems.    

Figure 5 in Dave’s article, seen above, shows the effect of the anti-vaping misinformation campaign that has been supported since 2012 by the transfer of hundreds of millions of dollars from the FDA to the National Institutes of Health to cooperating university researchers.  This scheme has generated hundreds of laboratory and epidemiologic studies reporting exaggerated or downright false vaping harm. 

The chart shows the success of the misinformation campaign from 2012 to 2019.  The percentage of Americans viewing e-cigarettes as more harmful than cigarettes grew at a consistent rate of about two percentage points per year. 

The 2019 EVALI debacle took the public’s fear of nicotine e-cigarettes and vaping products to new heights.  As Dave et al. write, “the immediate impact…was to increase the fraction of respondents who perceived e-cigarettes as more harmful than smoking by about 16 percentage points.”  After the CDC issued its December 10 tweet emphasizing “the role of THC e-cigarette products, e-cigarette risk perceptions were partially revised downwards.”

That downward movement was minimal, as Figure 6 from the analysis illustrates:



Dave et al. generously refer to the CDC’s delayed identification of marijuana as the cause of EVALI as “precautionary” but they suggest that it may have had “unintended consequences. More targeted advice about the risks of THC e-cigarettes might have more effectively reduced the use of those products, potentially preventing EVALI cases. Moreover, the increase in e-cigarette risk perceptions might discourage adult smokers from using e-cigarettes…the increase in e-cigarette risk perceptions might slow the downward trend in youth smoking.”

By not announcing early on that contaminated marijuana products cause EVALI, the CDC increased the number of injuries and deaths.  The agency inaction also discouraged smokers from switching and might have even encouraged teens to smoke.



Wednesday, November 29, 2017

FDA Releases More Positive Results for IQOS; British Medical Association Supports E-Cigs



I earlier reported (here) that Stanton Glantz, a University of California, San Francisco professor, urged the FDA to deny Philip Morris International’s application to market its IQOS heat-not-burn cigarette as a modified risk tobacco product, based on his comparison of lab results for IQOS users versus continuing smokers.  I noted that Glantz ignored data for IQOS users versus complete quitters, although that statistical comparison was not in the documents released by the FDA.

Additional data released by the FDA yesterday shows that PMI had submitted considerably more information from its Japanese study.  PMI reported data on exposure to carcinogens, carbon monoxide and nicotine, and, importantly, analyses for all of these results, including IQOS versus smoking, and IQOS versus quitting.

The following table shows all results after three months.  Differences in the table are described positively with respect to health (e.g., IQOS significantly lower).  “NS” indicates no significant difference between groups for that test.  The primary carcinogens are listed, with lengthy chemical metabolites abbreviated in parentheses.  

IQOS users were not significantly different than quitters with respect to inflammation, oxidative stress, blood pressure, lung function and carbon monoxide levels.  Compared with continuing smokers, IQOS users had significantly lower levels of 15 out of 16 carcinogen markers after 90 days of use.  There were no differences between IQOS and quitting for 13 of 16 markers.

My previous blog post was based on partial results released by FDA.  The agency’s latest release provides further evidence that toxin levels three months after switching to IQOS look more like complete quitting.

No one is claiming that IQOS is perfectly safe.  However, exposure to toxic agents among IQOS users is substantially lower than exposure among smokers, and very close to that associated with complete quitting.

In breaking news, the British Medical Association Board of Science has just issued a positive report on e-cigarettes (here).  Their findings, which likely apply to IQOS, appear below verbatim.

Is it safe to use an e-cigarette in the long-term?

In the absence of long-term studies it is not possible to be certain about the long-term health risks, but there is growing consensus that use of e-cigarettes is significantly safer than smoking.

Unlike cigarette smoking, e-cigarette use does not expose users to the products of combustion, and most of the toxicants causing smoking-related disease are absent or significantly reduced in e-cigarette vapour.

Indications to date are that complete switching can lead to improvements in the levels of toxins and carcinogens in urine similar to that in smokers who switch completely to NRT (nicotine replacement therapies).



Comparison of Laboratory Values: IQOS Users Versus Continuing Smokers and Versus Complete Quitters After 3 Months
Lab MarkerIQOS Versus SmokingIQOS Versus Complete Quitting*



Inflammation

White blood cell countIQOS significantly lowerNS
C-reactive proteinNSNS
Soluble ICAMIQOS significantly lowerNS
FibrinogenNSNS



Oxidative Stress

Prostaglandin F2 alphaIQOS significantly lowerNS
11-DTX-B2NSNS



Cholesterol, Triglycerides

High density lipoproteinIQOS significantly higherNS
Low density lipoproteinNSNS
Total cholesterolNSNS
TriglyceridesNSIQOS significantly lower



Blood pressure

SystolicNSNS
DiastolicNSNS



Lung function

Forced expiratory vol, 1 sec.NSNS



Carbon monoxideIQOS significantly lowerNS
CarboxyhemoglobinIQOS significantly lowerNS



NicotineNS*IQOS significantly higher



Carcinogens**

Nicotine-derived nitrosamine ketone (NNK)IQOS significantly lowerQuitting significantly lower
Butadiene (MHBMA)IQOS significantly lowerNS
Acrolein (3-HPMA)IQOS significantly lowerQuitting significantly lower
Acrolein (HMPMA)IQOS significantly lowerNS
Benzene (S-PMA)IQOS significantly lowerNS
Polycyclic aromatic hydrocarbons (1-OHP)IQOS significantly lowerNS
Polycyclic aromatic hydrocarbons (CYP 1A2)IQOS significantly lowerNS
N-nitrosonornicotineIQOS significantly lowerQuitting significantly lower
4-aminobiphenylIQOS significantly lowerNS
1-aminonaphthaleneIQOS significantly lowerNS
2-aminonaphthaleneIQOS significantly lowerNS
o-toluidineIQOS significantly lowerNS
Acrylonitrile (CEMA)IQOS significantly lowerNS
Styrene (HEMA)IQOS significantly lowerNS
Benzo(a)pyreneIQOS significantly lowerNS
Toluene (S-BMA)NSNS



NS, No significant difference
* IQOS results in nicotine levels that are similar to smoking
** carcinogen (chemical metabolites)


Thursday, March 9, 2017

E-Cigarette Toxic Chemical Exposure Is Same as for Nonsmokers



The new finding from British and U.S. e-cigarette researchers understated the good news for vapers.

“Long-term NRT-only and e-cigarette-only use…is associated with substantially reduced levels of measured carcinogens and toxins relative to smoking only combustible cigarettes,” reported scientists at the University College London; King's College, London; the Roswell Park Cancer Institute in Buffalo, New York; and the U.S. Centers for Disease Control and Prevention (CDC). Their work, with Lion Shahab as lead author, appeared in the Annals of Internal Medicine last month (abstract here). 

“The observed carcinogens and toxins” were a group of volatile organic compounds (VOCs), including acrolein, acrylamide, acrylonitrile, butadiene and a combination of ethylene oxide, acrylonitrile and vinyl chloride.  The researchers actually measured metabolites – products formed when the body breaks down the VOCs – in the urine.

The finding is good news for vapers, who avoid the thousands of toxins in smoke.  But the study and associated media coverage gave the impression that e-cigarette use also resulted in excess exposure to the VOCs.  That may not be true.

People are exposed every day to these VOCs, in the air and in our food and drinks.  Research published by K. Udeni Alwis et al. in 2012 (abstract here) showed that nonsmokers have measurable levels of these chemicals.    

Here are compared results from the Shahab and Alwis studies.  The former did not report absolute levels of the VOC metabolites; rather, it designated smokers as the referent group, and reported levels in vapers as a percentage of levels in smokers.  The Alwis study reported actual levels in smokers and nonsmokers, allowing me to calculate the percentages.       


Percentage Exposures to VOCs in Vapers (Shahab) and NonSmokers (Alwis), Compared to Smokers
VOCPercentage in VapersPercentage in NonSmokers



Acrolein33%26%
Acrylamide43%42%
Acrylonitrile2.9%2.5%
Butadiene11%18%
Combination*44%35%
*ethylene oxide, acrylonitrile and vinyl chloride


The table shows that VOC exposures in vapers were similar to exposures in nonsmokers.  For example, in the Shahab study, vapers’ exposure to acrylamide was 43% of the exposure among smokers, whereas nonsmokers’ exposure was 42% of smokers in the Alwis study.

The authors of the Shahab report, particularly Dr. Alwis (who is at the CDC), should have made the connection between the results of the two studies.  The fact that vapers’ VOC exposures are similar to those of nonsmokers is headline-worthy.