Showing posts with label e-cigarette. Show all posts
Showing posts with label e-cigarette. Show all posts

Tuesday, July 14, 2020

E-Cigarettes and Respiratory Disease: NO EVIDENCE


Drs. Dharma Bhatta and Stanton Glantz published a study in February’s American Journal of Preventive Medicine claiming that “Use of e-cigarettes is an independent risk factor for respiratory disease in addition to combustible tobacco smoking.” (here)  In a University of California San Francisco press release, Professor Glantz made additional claims: “We concluded that e-cigarettes are harmful on their own, and the effects are independent of smoking conventional tobacco…This study contributes to the growing case that e-cigarettes have long-term adverse effects on health and are making the tobacco epidemic worse.”

Now Cornell University researchers, led by economics professor Don Kenkel, have published a comprehensive re-analysis of that study (here), concluding:

We find no evidence that current or former e-cigarette use is associated with respiratory disease.

Kenkel and his co-authors explain why the Bhatta and Glantz claims are bogus: “The statistical associations that Bhatta and Glantz find between e-cigarette use and respiratory disease are driven by e-cigarette users who are also current or former smokers of combustible tobacco…almost all e-cigarette users were either current or former smokers of combustible tobacco. In the longitudinal analysis sample with 17,601 observations, there were only 12 current e-cigarette users who had never smoked combustible tobacco. None of the 12 respondents had incident (new) respiratory disease.”

In other words, while Bhatta and Glantz asserted that e-cigarettes were an “independent” risk factor for respiratory disease, only 12 vapers had never smoked and none of them developed the illness.

Last year, Bhatta and Glantz claimed in the Journal of the American Heart Association that e-cigarettes cause heart attacks.  Informed by my research group that many of the vapers’ heart attacks occurred years before they picked up their first e-cigarette, JAHA editors retracted that study in February.

It is important to note that Bhatta and Glantz used the same federal grants, totaling $13.6 million, to fund both the retracted JAHA heart attack study and the bogus AJPM respiratory disease study.  As I said in February, massive amounts of taxpayer dollars flowing to U.S. researchers who are anti-tobacco, anti-harm-reduction, in service of the government’s stated objective “to create a world free of tobacco use.”  Still, it is intolerable for public funds to be used in the production of scientifically unsound research.

The re-analysis by Kenkel and colleagues should prompt the American Journal of Preventive Medicine’s editors to revisit their decision to publish Bhatta and Glantz’s latest study.



Thursday, October 3, 2019

A False Connection Between E-Cigarettes and Heart Attacks


The Journal of the American Heart Association on June 5, 2019, published an article, “Electronic cigarette use and myocardial infarction among adults in the US Population Assessment of Tobacco and Health [PATH],” by Dharma N. Bhatta and Stanton A. Glantz (here).  In reading the article, I discovered that the authors misrepresented the research record;  presented a grossly inaccurate analysis of PATH Wave 1 survey data, and omitted critical information with respect to (a) when survey participants were first told that they had a heart attack, and (b) when participants first started using e-cigarettes.  The article reflected a significant departure from accepted research practices. 

The authors reported that current e-cigarette users were twice as likely as never users to have had a heart attack, based on information from 38 survey participants.  They reported odds ratios (ORs) of 2.25 (95% confidence interval, CI = 1.23 – 4.11) for 19 daily vapers, and 1.99 (CI = 1.11 – 3.58) for 19 some-day users (Abstract, Table 3 and Table S6).  Drs. Bhatta and Glantz claimed that their study confirmed that “e-cigarette use is an independent risk factor for having had a myocardial infarction…”  In a blog post on the University of California San Francisco website, Dr. Glantz cited the study as “more evidence that e-cigs cause heart attacks” (here).

I have extensive experience conducting research on the PATH data files.  I conducted an analysis of the Public Use Wave 1 data, which has no restrictions on release of results.  I found that at least 11 of the 38 current e-cigarette users were first told that they had a heart attack years before they first started using e-cigarettes. 

My research team conducted further analyses that were discussed in letters we sent to JAHA editors on July 11 and July 18; these letters were never acknowledged.  At the instruction of the Inter-university Consortium for Political and Social Research, I am not able to share those letters with you.